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Homepage | Drugs and Medication
Antidepressants May Help Body Fight Cancer, HIV
The Independent reports that new research published in inBiological Psychiatry indicates some antidepressants may help they body fight HIV, cancer and other infections.
Natural killer (NK) cells are white blood cells which home in on infected or cancerous cells, releasing agents that induce apoptosis, or "cell suicide". NK cells are especially active against viruses.
The research emerged from findings that stress and depression impair NK cell function and can accelerate the progress of HIV/ Aids. Scientists recruited depressed and non-depressed HIV-positive women and treated them with three drugs to treat stress and depression. Two, Citalopram and the "substance P antagonist" CP-96345 increased NK cell activity, while RU486 had no effect.
The Independent article also contained the following quote from the leader of the research team, Dr Dwight Evans of the University of Pennsylvania in Philadelphia: "The findings show that natural killer cell function in HIV infection may be enhanced by selective serotonin re-uptake inhibition and substance P antagonism."
It sounds promising. If additional research supports the theory it is possible more people suffering from HIV and/or cancer will also be put on an antidepressant. Many cancer patients already are because it helps with chronic pain management.
Posted on May 12, 2008
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There's Medicine in Our Drinking Water
An Associated Press probe has found traces of pharmaceuticals in the water supply of 41 million Americans. The amounts of individual medications in the drinking water is tiny but they include a wide range of meds including antibiotics and sex hormones.
A vast array of pharmaceuticals - including antibiotics, anti-convulsants, mood stabilizers and sex hormones - have been found in the drinking water supplies of at least 41 million Americans, an Associated Press investigation shows.
To be sure, the concentrations of these pharmaceuticals are tiny, measured in quantities of parts per billion or trillion, far below the levels of a medical dose. Also, utilities insist their water is safe.
But the presence of so many prescription drugs - and over-the-counter medicines like acetaminophen and ibuprofen - in so much of our drinking water is heightening worries among scientists of long-term consequences to human health.
Here's how the drugs get into the drinking water.
People take pills. Their bodies absorb some of the medication, but the rest of it passes through and is flushed down the toilet. The wastewater is treated before it is discharged into reservoirs, rivers or lakes. Then, some of the water is cleansed again at drinking water treatment plants and piped to consumers. But most treatments do not remove all drug residue.
It's very disturbing. No one wants to imagine drinking traces of all sorts of drugs when they are taking a drink. This is going to drive up the demand for bottled water - except that water contains drug traces too.
Even users of bottled water and home filtration systems don't necessarily avoid exposure. Bottlers, some of which simply repackage tap water, do not typically treat or test for pharmaceuticals, according to the industry's main trade group. The same goes for the makers of home filtration systems.
Concerned citizens need to pressure lawmakers to require stricter filtering of our drinking water.
Environmental News Service says the AP probe confirms a 2002 report by the U.S. Geological Survey that was the "first nationwide study of pharmaceutical pollution in the nation's rivers and streams."
Posted on March 10, 2008
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Nasal Spray Could Help the Sleep Deprived
Wired reports that scientists have discovered a brain hormone called orexin A that people could snort to reverse the effects of sleep deprivation. It has worked in monkeys. Sleep-deprived monkeys became alert with no ill effects - as if they had received plenty of sleep - after receiving a nasal spray containing the hormone.
A nasal spray containing a naturally occurring brain hormone called orexin A reversed the effects of sleep deprivation in monkeys, allowing them to perform like well-rested monkeys on cognitive tests. The discovery's first application will probably be in treatment of the severe sleep disorder narcolepsy.
The treatment is "a totally new route for increasing arousal, and the new study shows it to be relatively benign," said Jerome Siegel, a professor of psychiatry at UCLA and a co-author of the paper. "It reduces sleepiness without causing edginess."
Orexin A is a promising candidate to become a "sleep replacement" drug. For decades, stimulants have been used to combat sleepiness, but they can be addictive and often have side effects, including raising blood pressure or causing mood swings. The military, for example, administers amphetamines to pilots flying long distances, and has funded research into new drugs like the stimulant modafinil (.pdf) and orexin A in an effort to help troops stay awake with the fewest side effects.
It sounds promising. If it delivers as promised there were be many people interested in using it. You have to wonder though if someone were to use this frequently whether it would have an impact on memory or learning. Sleeping is thought to help the brain process information so would using a drug like this impact learning is the tiredness purely a chemical problem? Wired's story says it will be at least a decade before the drug described above would be available to humans here in the U.S.
Posted on December 28, 2007
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FDA Panel Warns on Cold Medicines for Children Under 6
A FDA panel has warned that over-the-counter (OTC) cold and cough medicines do not work in children and that they should not be used in children less than six years old. The medicines the FDA Panel is warning about includes decongestants, antihistamines and antitussives but not expectorants. Over a dozen cold products for infants were recently pulled off store shelves. UPI reports that the panel has voted 13 to 9 to also ban cold medicines targeted at kids 2 to 5 years old. However, products for kids aged 2 to 5 years old have not been banned by the FDA.
A CNN article says that one member of the panel - the patient representative - was concerned that if there were no child drugs available then parents would use adult medications instead.
While the panel overwhelmingly said the products haven't been proven to work in children 11 and younger, the panel, by a vote of 15 to 7, stopped short of recommending the products not be used at all in older children.
Amy Celento-Stamateris, the patient representative on the panel, said if there were no children's cold and cough products on the market, "there are many people who will administer (adult) products to their children because they work for them and I'd be very concerned."
An MSNBC article says the news has really confused parents. There is no cure for a cold virus so many parents use the OTC drugs to soothe their child's symptoms. Parents with kids with allegy and asthma may be extra concerned when a child comes down with a cold.
The advice has left many parents wondering what to do when their kids are suffering from stuffy noses, sniffles or hacking coughs.
"You've got to take it seriously. I want to be cautious," says Alison Schwartz, a 36-year-old mom who lives in Sacramento, Calif. "But on the other hand, it's really hard with a child - especially a kid under 6 - to watch him up all night coughing, with a cold or the flu, and not be able to give him something to give him a little relief, just so he can get some sleep."
Like many parents, Schwartz argues that the over-the-counter cold medicines have always seemed to work for her son, 3-year-old Owen.
The FDA meeting came just a week after several manufacturers pulled sales of nonprescription cold drugs targeted at children under 2. The move followed questions by the FDA and other health groups over a number of reported deaths linked to the remedies in recent years. The deaths occurred when parents gave their children accidental overdoses.
It's troubling news for many parents who now aren't sure how to best care for a child with a cold.
A New York Times article says mothers are split over the news. An MSNBC article says these methods are best for infants with colds.
Plenty of fluids and rest.
Suction bulbs to gently clear infants' clogged noses. Saline nose drops loosen thick secretions so noses drain more easily.
A cool-mist humidifier in the child's bedroom.
Acetaminophen or ibuprofen, as recommended by your doctor, to alleviate pain or discomfort - but check that they don't contain extra ingredients.
Some chest creams can ease stuffiness with menthol or other fragrances, but check labels for age restrictions.
The FDA also recently issued this warning about infants and cold drugs. You can also find information from the Consumer Healthcare Products Association (CHPA) at otcsafety.org.
Posted on October 19, 2007
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Publix Won't Charge For Seven Popular Prescription Antiobiotics
The Sun-Sentinel reports that the Publix grocery store chain will be giving away several popular prescription antiobiotics as a way to lure customers to stores. The drugstore will give away the following drugs: amoxicillin, cephalexin, penicillin VK, erythromycin, ampicillin, sulfamethoxazole/trimethoprim, and ciprofoxacin.
The oral antibiotics, representing the most commonly filled at the chain's pharmacies, will be available at no cost to anyone with a prescription as often as they need them, Publix CEO Charlie Jenkins Jr. said. Fourteen-day supplies of the seven drugs will be available at all 684 of the chain's pharmacies in five Southern states.
The prescription antibiotics available under the program are amoxicillin, cephalexin, penicillin VK, erythromycin, ampicillin, sulfamethoxazole/trimethoprim, and ciprofoxacin.
Gov. Charlie Crist went to a suburban Fort Myers store to help the company make the announcement and to praise the Lakeland-based employee-owned company, one of the dominant retailers in the region.
"It can't be any more affordable than free," Crist said.
Last year Wal-Mart started selling sell generic prescription drugs for $4. Kmart offers a 90-day supply of generic drugs for $15. The article says several other retailers also offer discounted drugs but Publix is the first to give them away.
Posted on August 6, 2007
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FDA Considering Drug Report Cards
The FDA is considering issuing drug report cards that inform the public about problems with drugs and drug side effects. This would be for drugs that the FDA has already approved. MSNBC.com reports the FDA is looking for new ideas following the "public outcry over the withdrawal of the painkiller Vioxx."
As part of a pilot program, the Food and Drug Administration will issue drug “report cards” that would detail unexpected side effects that emerge only after a drug has been approved. The reports also would include follow-up studies and details about how the drugs are being used.
The proposal is one of roughly a dozen initiatives, new and ongoing, that the FDA unveiled Tuesday in response to a recent report by a committee of experts at the Institute of Medicine that criticized the agency's handling of drug safety in the wake of the Vioxx case.
It comes just days before Sens. Edward Kennedy, D-Mass., and Mike Enzi, R-Wyo., introduce legislation to overhaul how the FDA handles drug safety.
"Today's report is thoughtful and provides important recommendations for administrative action, but only legislation can give FDA the tools it needs to ensure that FDA is the gold standard for safety," Kennedy said in a statement.
The drug report cards are something the FDA is considering but nothing has been decided. The Associated Press says the FDA did say it will "publish newsletters to summarize its safety reviews of older drugs and disclose emerging issues." You can find drug information currently on the FDA's website on this webpage. Each drug has a Drug Information Page. For example, the page for Aciphex can be found here. It includes information about the drug as well as a date indicated when the information was last updated.
Posted on January 30, 2007
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Skin Patches May Replace Shots
MNSBC.com reports that skin-patch vaccines are being tested that could replace shots. If effective this could be an excellent method for distributing a vaccine to a large number of people in an emergency -- the skin-patches could be delivered in the U.S. mail.
Early tests of skin-patch vaccines are beginning in hundreds of volunteers, one version designed to protect against the flu and another to prevent travelers' diarrhea.
The idea isn't just pain-free vaccination. The National Institutes of Health is helping fund patch research in hopes of strengthening today's imperfect flu shots, and gaining extra help if bird flu or some other super-flu ever triggers a pandemic.
Indeed, patch developer Iomai Corp. proposes that the mailman, not a doctor, deliver flu vaccine during a pandemic. Once a vaccine is brewed, simply ship patches to people's homes with instructions to slap one on.
Doctors might not like the go-it-alone method. But the technology's main promise may be in developing countries. Unlike syringe-based vaccines, patches wouldn't need refrigeration — nor pose the infection risk of reused needles, a continuing problem.
If it works -- and the skin-patch method is as powerful and effective as a shot -- it would certainly make allergy and flu prevention a lot easier. It would also make a lot of little shot-fearing kids much happier.
Posted on November 6, 2006
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Wal-Mart to Sell Generic Prescription Drugs for $4
Wal-Mart has launched a plan to sell generic prescription drugs for $4. The program will cover 294 general prescription drugs to start with. The first Wal-Mart stores to run the plan will be in the Tampa Bay, Florida area. In January 2007 Wal-Mart will expand to cover the rest of Florida. Here are some of the key components of the plan according to a Wal-Mart press release.
The $4 pricing will be available to all pharmacy customers with a prescription from a doctor that can be filled with a covered generic medicine.
This program will be available to the uninsured.
Insurance will be accepted.
The program presently covers 291 generic medications from many of the most common therapeutic categories.
The medicines represented are used to treat and manage conditions including allergies, cholesterol, high blood pressure and diabetes. Some antibiotics, antidepressants, antipsychotics and prescription vitamins are also included.
The program will be available statewide in Florida in January 2007.
Wal-Mart intends to take the program to as many states as possible next year.
More coverage of Wal-Mart low generic prices can be found on US News and NPR.
Update 9-23-06: USA Today reports that Target has announced plans to match Wal-Mart $4 price on generic drugs in the Tampa Bay area.
Photo by kissthis
Posted on September 22, 2006
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Report Accuses Drug Firms of Exaggerating and Inventing Diseases
The BBC explains a new report from Public Library of Science Medicine that accuses pharmaceutical companies of "inventing diseases" so they can sell more drugs.
Report authors David Henry and Ray Moynihan criticised attempts to convince the public in the US that 43% of women live with sexual dysfunction.
They also said that risk factors like high cholesterol and osteoporosis were being presented as diseases -- and rare conditions such as restless leg condition and mild problems of irritable bowel syndrome were exaggerated.
The report said: "Disease-mongering is the selling of sickness that widens the boundaries of illness and grows the markets for those who sell and deliver treatments."
The article listed restless legs, irritable bowel syndrome and menopause as some of the examples of conditions where disease-mongering was occuring. People suffering from IBS would probably disagree. In addition to accusing drug companies of "inventing ailments" critics have also accused drug firms of running advertisements that are vague about what exactly the drug being advertised is supposed to treat.
Posted on April 17, 2006
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US Health Experts Say Cough Medicines Are Not Helpful
The BBC reports that the American College of Chest Physicians has published new guidelines that says there is "no clinical evidence" that OTC cough medicines work.
They suggest adults should use older non-prescription antihistamines and decongestants to stop the flow of mucus that causes the cough.
Children can be harmed by cough medicines, they warn, and they will usually get better without help.
It is possible children could be over-sedated with the medication, they said.
Yahoo Health has an entire page on coughs. Yahoo Health says there are two different kinds of coughs -- productive coughs and nonproductive coughs. Here is what they say about productive coughs:
A productive cough produces phlegm or mucus (sputum). The mucus may have drained down the back of the throat from the nose or sinuses (postnasal drainage) or may have come up from the lungs. A productive cough generally should not be suppressed; it clears mucus from the lungs.
Here is what they say about nonproductive coughs:
A nonproductive cough is dry and does not produce sputum. A dry, hacking cough may develop toward the end of a cold or after exposure to an irritant, such as dust or smoke.
Obviously people who regularly suffer from raw or soar throats, like allergy sufferers, are going to want something that makes their throat feel better even if their is "no clinical evidence" that they work. ShoppingBlog.com says "We're not doctors and this has nothing to do with coughing, but when we get allergy-related sore throats, we swear by Ricola sugar-free lemon drops. And we're not giving them up."
Posted on January 10, 2006
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The Power of Crocodile Blood
Reuters reports that scientists in Australia are collecting crocodile blood in the hopes that they will be able to create powerful drugs based on their research. Crocodiles have a much more powerful immune system than humans.
Initial studies of the crocodile immune system in 1998 found that several proteins (antibodies) in the reptile's blood killed bacteria that were resistant to penicillin, such as Staphylococcus aureus or golden staph, Australian scientist Adam Britton told Reuters on Tuesday. It was also a more powerful killer of the HIV virus than the human immune system.
"If you take a test tube of HIV and add crocodile serum it will have a greater effect than human serum. It can kill a much greater number of HIV viral organisms," Britton said from Darwin's Crocodylus Park, a tourism park and research center.
In the Reuters article scientists said that it will take several years before any human antibiotics developed from the crocodile blood will be available.
Posted on August 22, 2005
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Think Tank: Usage of Brain Boosting Drugs Will Become Common
BBC News reports that Foresight, a think thank, believes that brain-boosting drugs will see common usage within twenty years. The article says that drugs like Ritalin and Modafinil have already been shown to help people's concentration and memory. The Foresight study even suggested that cognitive enhancers could be used with the frequency that coffee is used today.
Ritalin, now prescribed to children with attention deficit hyperactivity disorder (ADHD), has already been used by some students to improve their performance in exams.
Modafinil, used now to treat sleep disorders, has been shown to help people remember numbers more effectively.
It can also make people think more carefully before making decisions.
There is also a type of molecule called ampakins, which enhance the way some chemical receptors in the brain work, suggesting drugs could be developed to improve people's memory when they are tired.
Posted on July 13, 2005
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ATM-Like Machines Dispense Refills
New ATM-like devices, the ScriptCenter (picture on right) and the Automated Pharmacy Machine from Distributed Delivery Networks Corp. (DDN), can dispense perscription refills to patients. The Wall Street Journal reports that the devices have already been cleared for use in California and Virginia. There is concern among pharmacists that patients might get the wrong
drug by mistake or neglect to find a pharmacist and ask important questions about dosage and drug interactions.
The ATM-like machines are raising questions among pharmacists and state regulators who oversee prescription-drug dispensing. One worry is that patients might end up with the wrong drug. Some pharmacists also don't like the machines because they cut out traditional face-to-face consultations with patients. The concern is that patients might be discouraged from asking pharmacists about such things as whether alcohol should be avoided with a medicine, or possible drug interactions.
"There's lots of leeriness on the part of regulators and the fear that something like this could replace the pharmacist," says Mary Ann Wagner, vice president of pharmacy regulatory affairs for the National Association of Chain Drug Stores, a trade group in Alexandria, Va.
(Via MedGadget)
Posted on June 30, 2005
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Study: 27% Believe Drug Companies Hiding Cancer Cure
Dr. Koop reports on a new study that indicates some Americans distrust the drug companies. According to the survey 27% of Americans believe that a cancer cure already exists but the health industry is hiding it. 41% believe that the surgical treatments used to cure cancer actually spread the disease. And 89% disagreed with the statement that "all you need to beat cancer is a positive attitude." Dr. Ray DuBois, director of the Vanderbilt-Ingram Cancer Center in Nashville, Tenn, told Dr. Koop that drug companies are not hiding a cancer cure.
Most surprising, he said, was the widespread belief that the medical industry is hiding a cure. "It's just the reverse," DuBois said, noting that companies are trying to fast-track new drugs and treatments to get them to people as soon as possible.
The survey results, said DuBois, probably mean that cancer centers should "beef up their public education efforts." He noted, "There are more misconceptions out there than some people realize."
Posted on June 27, 2005
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