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Homepage | Diagnostic Procedures and Tools

New Scanner Greaty Improves Resolution While Reducing X-Ray Exposure

3D Heart ScanA new 256-slice CT machine from Philips creates some stunning images that medical professionals can use to find abnormalities and disease. The BBC reports that the new machine produces "3D body images of unprecedented clarity" while also reducing X-ray exposure by as much as 80%.
The new 256-slice CT machine takes large numbers of X-ray pictures, and combines them using computer technology to produce the final detailed images.

It also generates images in a fraction of the time of other scanners: a full body scan takes less than a minute.

The Philips machine was unveiled at the Radiological Society of North America.

Because the images are 3D they can be rotated and viewed from different directions - giving doctors the greatest possible help in looking for signs of abnormalities or disease.

All images also can be accessed on any computer in a hospital or by colleagues and researchers remotely, to make it easier for the whole team to share information.
Getting greating increase resolution combined with a reduction in radiation exposure is definitely a plus plus. The downside is it make a take a while for the new technology to make its way to local hospitals and clinic. The BBC story also includes a video that contains some of the scans. Looking at the scans it is obvious that this is a big step up in clarity.

Posted on November 27, 2007
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Alzheimer's Blood Test Developed

The BBC reports that a new blood test can identify Alzheimer's six years before symptoms of the disease start to show. The article says the blood test has a 90% accuracy
The test identifies changes in a handful of proteins that cells use to convey messages to one another.

The US researchers found it could indicate who had Alzheimer's, as well as who was likely to develop the condition, with 90% accuracy.

The work, led by Stanford University, features in Nature Medicine.

One of the most distressing aspects of Alzheimer's disease is the difficulty in determining whether mild memory problems are the beginning of an inevitable mental decline.
It sounds very promising. Early diagnosis of Alzheimer's disease should make it easier to eventually halt or reverse the progress of the disease. Hopefully, the test won't falsely identify someone as having Alzheimer's. You wouldn't want a situation where people were falsely accused of having a disease which causes progressive mental decline.

Posted on October 16, 2007
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New Blood Test May Measure Visceral Fat

The BBC reports that a new blood test that measures the amount of a protein called RBP4 in the blood may help determine the amount of fat around a person's internal organs. The scientists doing the research are hopeful that cutting RBP4 may have health benefits.
The researchers believe that measuring RBP4 would potentially be an effective way to assess body fat, and that treatment to cut levels of the protein might also have health benefits.

In previous work, they showed that cutting RBP4 levels in obese mice helped the animals to make better use of the hormone insulin - and thus reduce their risk of diabetes.

They also showed that measures to improve insulin sensitivity in human subjects resulted in a drop in RPB4 levels.

Researcher Dr Matthias Bluher said: "We believe that in the near future, measurements of RBP4 serum concentrations might serve as a novel biomarker for visceral obesity and increased risk for type 2 diabetes and other adverse outcomes of visceral obesity.

"In addition, pharmacological interventions that reduce RBP4 levels might be a new approach in the treatment of metabolic syndrome and visceral obesity."

The only known function of RBP4 is to carry vitamin A in the blood.
Measuring visceral fat is important because just because people appear fat on the outside doesn't mean they have a lot of visceral fat. There are also people known as tofis (thin on the outside, fat on the inside) who appear thin but carry a lot of visceral fat, or fat around their internal organs.

Posted on September 26, 2007
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Elastrography Can Instantly Identify Breast Cancer

MSNBC.com reports that experimental ultrasound technology called elastography has been very successful in early trials at locating cancer. Elastrography is able to instantly indicate whether a breast lump is cancer or a benign lesion.
An experimental ultrasound technique that measures how easily breast lumps compress and bounce back could enable doctors to determine instantly whether a woman has cancer or not without doing a biopsy.

In a small study of 80 women, the technique -- called "elastography" -- distinguished harmless lumps from malignant ones with nearly 100 percent accuracy.

If the results hold up in a larger study, elastography could save thousands of women from the waiting, cost, discomfort and anxiety of a biopsy, in which cells are removed from the breast -- sometimes with a needle, sometimes with a scalpel -- and examined under a microscope.
The article says that of the 1 million biopses performed on breast lump each year about 80% of them turn out to be benign. This causes women a great deal of stess and fear and wastes a lot of time and money simply because today's technology is not perfect.
"There's a lot of anxiety, a lot of stress, a lot of fear involved" with biopsies, said Susan Brown, manager of health education for the Susan G. Komen Breast Cancer Foundation. "And there's the cost of leaving work to make a second appointment. If this can be done instead of a biopsy, there would be a real cost reduction."
Here's how Jonathan Ophir, one of the pioneers of the test, explains the technology.
To explain elastography, Ophir likens the body to a box-spring mattress, but "a crazy mattress made out of millions of small springs and each one is a little different. Each is moving around at a different rate, depending on their individual stiffness." Cancerous tumors are like stiff springs. Normal tissue and benign lesions compress more easily.
The article cited some doctors that believe elastrography will be used in the future but that biopses will probably continue both for legal reasons and because doctors don't want to miss diagnosing a possible cancerous tumor. You can read more about elastrograhy on elastrography.com.

Posted on December 8, 2006
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Study Tests Google as a Diagnostic Tool

A research study has found that using Google can be a useful diagnostic tool. The study found Google searches revealed the correct diagnosis in 15 out of 26 cases (58%).
Setting One year's (2005) diagnostic cases published in the case records of the New England Journal of Medicine.

Cases 26 cases from the New England Journal of Medicine; management cases were excluded.

Main outcome measure Percentage of correct diagnoses from Google searches (compared with the diagnoses as published in the New England Journal of Medicine).

Results Google searches revealed the correct diagnosis in 15 (58%, 95% confidence interval 38% to 77%) cases.

Conclusion As internet access becomes more readily available in outpatient clinics and hospital wards, the web is rapidly becoming an important clinical tool for doctors. The use of web based searching may help doctors to diagnose difficult cases.
Search does seem like a valuable tool for doctors trying to determine a possible diagnose based on a variety of symptoms. The Internet has definitely helped a lot of patients communicate with people suffering from similar diseases and conditions. (via WebProNews.com)

Posted on November 13, 2006
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VeinViewer Could Help Nurses Find Veins for IVs

Vein ViewerGE's BloggingNEXT blog reports on a new technology called Veinviewer that makes it easy to view the structure of a person's veins.
This isn't a GE product - but it's fascinating. Anyone who's ever gotten an IV knows how unpleasant the process can be. The Veinviewer is fast (no waiting for a scan) and uses simple near-infrared light, a digital video camera, and a digital video projector (using DLP technology from Texas Instruments) to project onto your skin an image of the vein structure below. It's tough to overstate how simple and easy this is.
Here is Luminetx description of its VeinViewer technology.
The VeinViewer by Luminetx uses a combination of near-infrared light and patented technologies to image vascular structures, thus allowing physicians, nurses and other healthcare professionals to clearly see accessible vasculature (or lack thereof) in real time, directly on the surface of the skin.
Hopefully, this technology will be used in hospitals and it will help to reduce the number of unsuccessful sticks patients have to suffer through before a vein is found for the IV.

Posted on September 29, 2006
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Skin Test Might Help Diagnose Alzheimer's Early

Forbes.com reports that researchers are working on a skin test that might help with early detection of Alzheimer's disease.
The test zeroes in on two forms of an enzyme involved in the degradation of amyloid, the protein that accumulates in the brain of someone with Alzheimer's, said Alkon, scientific director of the Blanchette Rockefeller Neurosciences Institute at the West Virginia University Health Sciences Center.

The presence of Alzheimer's disease is indicated by a steep imbalance in the ratio of the two forms of the enzyme, MAP kinase Erk, in skin cells that are exposed to bradykinin, an inflammation-related molecule, Alkon said. That imbalance is not seen in cells of people without dementia or those with other forms of dementia, he said.

The test produced good results when run on 60 tissue samples: 30 from a tissue bank, 30 from autopsy samples of people diagnosed with Alzheimer's disease, Alkon said.

"We have seen a correlation with the duration of the disease," he said. "The earlier it is done in the course of the disease, the larger is the abnormality."
The skin test is still far from being reader but the article does say they are ready to expand to a large test of 1,000 people. So, we now have the skin test that medical experts are working as well as the alzheimer's eye tests we mentioned last month.

Posted on August 14, 2006
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Wristwatch Helps With Supervision of Elderly Patients

ExmocareExmocare has launched a web-based bluetooth-enabled biosensor wristwatch service. The service is aimed at helping with medical supervision of the elderly. The services includes a wristwatch that monitors its wearer's pulse, heart rate variability, skin conductance and activity level via a built in accelerometer. Exmocare says the wristwatch can also provides rudimentary assessments of up to 10 different emotional states, including when its elderly wearer is relaxed, upbeat, worried, agitated, etc. The wristwatch can be used to send alerts to families and/or health care providers using SMS, email and/or instant messenger.

Posted on August 4, 2006
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Scientists Hope Simple Eye Scans Could Detect Alzheimer's

The BBC reports that scientists have discovered that infrared lights could be used to identify people with very early stages of Alzheimer's disease. Scientists have developed a test that checks for deposits of beta-amyloid. Early tests have been successful in mice.
During the trial, a brief pulse of infrared light into the eyes of four mice with Alzheimer's and four without accurately identified which had the condition.

Dr Goldstein and his team envisage the test could be used to detect the disease at its earliest stages as well as to track disease progression and monitor how people respond to Alzheimer's treatments.

Currently there is no simple test to make a diagnosis of dementia and it can only be confirmed with certainty by looking at someone's brain in a post-mortem examination.

The scientists believe the technology, known as quasi-elastic light scattering, may detect the very earliest stages of amyloid deposits in the lens, even when they appear completely clear to the naked eye.
It might help with prevention and finding a cure if doctors are able to diagnose alzheimer's in its very early stages. However, it would also be very alarming to have such a serious diagnosis from a simple eye exam.

Posted on July 25, 2006
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Gold Nanoparticles Could Verify the Presence of Biological Toxins

The BBC reports that UK researchers have found that gold nanoparticles can be used to rapidly detect the presence of biological toxins. The test could even estimate how much of a toxin is present.
The research makes use of gold nanoparticles that are only 16 nanometres in diameter - roughly 1/5000th the width of a human hair.

Earlier work by Professor Russell's team has refined manufacturing methods so relatively large amounts of the particles can be made quickly.

Once made, the particles are coated with sugars tailored to detect different biological substances.

When mixed with a weak solution of the sugar-coated nanoparticles, the target substance, be it a poison such as ricin or a bug like E.coli, binds to the sugar. This changes the properties of the solution and makes it change colour.
This concept could have many very important uses from preventing bio-terrorism to verifying whether water is safe to drink.

Posted on April 7, 2006
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Tiny Pill Helps Monitor Temperature

IEEE Spectrum Online reports that a radio pill originally created to help measure the temperature of NASA astronauts will now be applied on the football field to monitor player's temperatures.
The radio pill, part of the CorTemp Physiological Monitoring System manufactured by Palmetto, Fla. based HQ Inc., relies on a temperature-sensitive quartz crystal oscillator whose vibration frequencies are well known for temperatures ranging from ­60 °C to 150 °C. For instance, the crystal oscillates at 262.25 kilohertz at the normal body temperature of 37 °C. The electronic components calculate the temperature and transmit the data as a digital signal. Power comes from a silver oxide hearing aid battery that holds enough energy for nine days of temperature readings. The capsule remains in the body for only 24 to 36 hours before it is eliminated.

The temperature readings are transmitted wirelessly to a handheld receiver­data recorder. As the digital signal induces a voltage on the pill's communication coils, this voltage creates a quasistatic magnetic field with a radius of about a meter. When a coach or trainer holds the receiver to the small of a player's back, a magnetic coupling between the pill and the receiver induces a voltage in the handheld device's antenna, which is then demodulated to retrieve the original temperature data.

Because magnetic communication does not generate a propagating wave and there is strong attenuation of the signal with distance, the data are hard to intercept and virtually free from interference-even if there are dozens of other players running around the practice field with radio pills in their guts. Creating such a magnetic communication bubble also requires very little power, which allowed the radio pill's designers to use the tiniest of commercial batteries.
The article also says the pills might be useful for soldiers in Iraq where several soldiers have died from heat-related illness. A description of the product can be found here on the manufacturer's website. (Via Boing Boing)

Posted on January 13, 2006
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Home HIV Testing in Twenty Minutes

The BBC reports that the US Food and Drugs Administration is considering making a fast HIV test available for home use. The test from Orasure Technologies just takes twenty minutes and people can use a swab sample instead of a blood test.
An individual would be able to tell within 20 minutes whether they had the infection or not, in the privacy of their own home.

Many have expressed fears that people who find out in this way may kill themselves and hence testing should be supervised and counselled face to face.

Home HIV testing kits are banned in the UK for such reasons. However, some buy unapproved kits over the internet.
The BBC article says that there is currently a test available in the U.S. where you prick your finger, mail in a blood sample and then contact a phone number anonymously to learn the results. The test from OraQuick definitely sounds quicker, easier and more private.

Posted on October 15, 2005
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E-noses Sniff for Bacteria

Scientists are working on e-noses that can decipher a particular smell pattern to determine if a deadly bacteria is present. The BBC reports on one e-nose scientists are working on that can detect the MRSA superbug in hospitals.
Getting a quick result is important for hospital screening and isolating infected patients to prevent disease outbreaks.

The e-nose gives a result within minutes, which is much faster than the current way of analysing ear, nose and throat swabs, which involves sending samples off to the lab and waiting 72 hours for a result.

Tests on hospital patients showed it could correctly detect three strains of Staph aureus, including MRSA, with more than 99% accuracy.

However, it cannot yet distinguish MRSA from its close cousin MSSA (methicillin-sensitive Staph aureus), which does respond to convetional antibiotics unlike MRSA.
Devices like e-noses, once 100% reliable, could be very beneficial to society. Conceivable uses for e-noses could range from tests on food in grocery stores to quick e-nose tests that could be used in business, by school nurses or used at home.

Posted on September 25, 2005
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Breath Tests to Identify Disease?

USA Today reports on a product from Menssana Research called Breathscanner 1.0 that can test the breath of a heart transplant patient to see if heart transplant is being rejected.
Experts caution, however, that while breath tests are a promising diagnostic technique, it does not appear that they will completely replace trusted methods such as biopsies and CT scans.

In the meantime, Phillips is looking to license a company to produce and market his Heartsbreath test to doctors and hospitals, since such a nationwide effort cannot be undertaken by his four-person firm.

Analyzing breath to diagnose disease is a concept that dates back two millennia, Phillips said, noting that ancient physicians found that a diabetic's breath smelled like rotten apples. And while a police Breathalyzer is designed to detect just one substance — alcohol — the acetone that causes diabetic breath is among the 200 compounds that the Heartsbreath technology can identify.

In addition, Phillips said, his technology can determine the levels of each compound, being about a billion times more sensitive than police machines.
It would be terrific for patients if simpler tests that measure blood and breath, like this particular test, can be used to help reduce the number of invasive biopsies performed on patients suspected of having cancer. (Via Medgaget.com)

Posted on August 24, 2005
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Brain Scans May Show Alzheimer's Risk

MSNBC.com reports that scientists have discovered that brain scans indicating a lower energy use by the hippocampus may indicate a likelihood of future Alzheimer's disease or other mental health problems nine years before any symptoms develop.
Still, the discovery may provide leads to scientists searching for therapies to at least delay the onset of the degenerative brain disease. It already affects 4.5 million people in the U.S. and is predicted to strike 14 million by 2050 as the population ages.

Moreover, researchers are honing in on lifestyle choices that may help protect the brain in the first place.

"It's exciting that we can even talk about prevention," said William Thies, scientific director of the Alzheimer's Association. He noted that just 10 years ago there was hardly any research into that possibility.
The Alzheimer's Association also issued a press release listing several lifestyle factors that may increase or decrease your chance of getting Alzheimer's. Some of their findings include:

  • Decreasing social activity is associated with increased risk of dementia.
  • Fruit and vegetable juices may reduce risk for Alzheimer’s disease
  • Exercise and moderate alcohol consumption may boost brain health

    Posted on June 21, 2005
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