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Homepage | Diabetes
New Blood Test May Measure Visceral Fat
The BBC reports that a new blood test that measures the amount of a protein called RBP4 in the blood may help determine the amount of fat around a person's internal organs.
The scientists doing the research are hopeful that cutting RBP4 may have health benefits.
The researchers believe that measuring RBP4 would potentially be an effective way to assess body fat, and that treatment to cut levels of the protein might also have health benefits.
In previous work, they showed that cutting RBP4 levels in obese mice helped the animals to make better use of the hormone insulin - and thus reduce their risk of diabetes.
They also showed that measures to improve insulin sensitivity in human subjects resulted in a drop in RPB4 levels.
Researcher Dr Matthias Bluher said: "We believe that in the near future, measurements of RBP4 serum concentrations might serve as a novel biomarker for visceral obesity and increased risk for type 2 diabetes and other adverse outcomes of visceral obesity.
"In addition, pharmacological interventions that reduce RBP4 levels might be a new approach in the treatment of metabolic syndrome and visceral obesity."
The only known function of RBP4 is to carry vitamin A in the blood.
Measuring visceral fat is important because just because people appear fat on the outside doesn't mean they have a lot of visceral fat. There are also people known as tofis (thin on the outside, fat on the inside) who appear thin but carry a lot of visceral fat, or fat around their internal organs.
Posted on September 26, 2007
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Diabulimia: Diabetic Young Women Skipping Shots to Lose Weight
The BBC is reporting that thousands of young women and teenage women with type 1 diabetes are intentionally skipping injections to fuel weight loss.
People with type 1 diabetes need daily injections to help them absorb glucose to use as fuel. Failure to take correct doses can lead to rapid weight loss.
Charity Diabetes UK estimates that up to one-third of young women with the disease miss injections to stay thin.
Doctors warn that the "diabulimia" eating disorder can lead to blindness, heart and kidney disease.
US doctors recently went public on their concerns about the practice.
It is very sad to read about teen girls and young women suffering from type 1 diabetes engaging in the very dangerous behavior of skipping insulin shots simply to lose weight. You can read more about diabulimia here and here. A personal story about diabulimia can be found here.
Posted on July 4, 2007
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Tofi: Thin on the Outside, Fat on the Inside
Not everyone who appears thin on the outside is also thin where it really matters -- on the inside. There is a word for this kind of people. The word is tofi and it stands for thin on the outside, fat on the inside. The Guardian reports that internal fat has been linked to serious health risks including diabetes and heart disease. Thanks to MRIs doctors are now able to determine whether or not people carry too much internal fat.
Bell has spent years studying how human beings store and use their adipose tissue, or fat. He has carried out studies showing that people who would be considered slim can have large quantities of fat within them.
'This is particularly true of men who have a slim build but who do little or no exercise,' he said. 'We know now that 40 per cent of people have fat infiltration of the liver, which is linked to so many other health problems.'
He said of Schwartz: 'He is slim, he's not overweight, but you can see there are some areas where there is a bit of a build-up of visceral fat. He doesn't have a lot of subcutaneous fat [the kind that lies just under the skin], but I can see there is quite a bit around the organs and some in the muscle.'
Thanks to this new technique, Bell and others are able to understand why appearances can be so deceptive. Someone like Schwartz, who is young, falls into the category of those who need to start changing their lifestyle. Unknowingly, he is on the way to becoming what is jokingly described as a 'Tofi' - Thin on the Outside, Fat on the Inside. Tofis probably need to worry more about their health than others, because the fat deposits they carry are hidden in the white fat that lies around their vital organs, streaked through their underused muscles, and wrapped around the heart. It is this fat that sends out the chemical signals which eventually lead to insulin resistance, diabetes and heart conditions, rather than the fat lying in dimples underneath the skin.
The findings about Tofis throughs out the useless BMI factor that has sidetracked many physicians. The study looked at Sumo wrestlers who have a very high BMI but very little internal fat.
What really counts, says Bell, is how and where the body's energy supply is stored. Fat cells are extremely intelligent - 'versatile players', as the American obesity specialist Roger Unger called them - which hang on stubbornly even through crash diets. For years, doctors saw fat tissue as a kind of passive storage compartment, but new research has shown that the fat cells, or adipocytes, are dynamic beings.
In Japan, sumo wrestlers have been put through MRI scanners to look at their fat composition. Even though they have a BMI of 56 and are eating up to 5,000 calories a day, they have very little internal fat. 'They have low cholesterol, they have low insulin resistance and a low level of triglycerides [fatty acids],' said Bell. 'Their fat is all stored under the skin, on the outside.'
The bottom line is you need information about a person's internal and external fat before you can make any kind of judgement about how healthy they are.
Posted on December 15, 2006
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Study Finds Number of Overweight Babies Increasing
The Boston Channel reports on a shocking new study that has found that the number of overweight babies and small children has increased significantly in the last twenty years. The study conducted over a twenty year period found that the number of overweight babies between birth to 6-months-old has jumped 74%.
"The rate of overweight babies has increased quite dramatically in 0- to 6-year-olds over a 20-year period," Dr. Matthew Gillman said.
Gillman was part of the study that looked at more than 120,000 children under 6 in Massachusetts.
"What was most surprising about our study is that we found the rate of among youngest children -- our infants -- was rising over this time," he said.
According to the study, overweight babies between birth to 6-months-old increased by 74 percent. Researchers said that translates into babies becoming overweight adults. It's an increase of 60 percent.
It sounds bad and it could be if these babies are being born with serious weight issues. Meanwhile, an article on WebMD talks about a study from India that found higher baby weight led to leaner adults. And then there is another study that suggests rapid infant weight gain may be a sign of future obesity problems in childhood. Where the infant weight gain is disturbing is if it is bad enough that it leads to adolescents with heart disease and type 2 diabetes as this MedlinePlus article explains.
Posted on August 16, 2006
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